Phycomysterols and other sterols from the fungus Phycomyces blakesleeanus.

نویسندگان

  • A F Barrero
  • J E Oltra
  • J A Poyatos
  • D Jiménez
  • E Oliver
چکیده

In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.

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عنوان ژورنال:
  • Journal of natural products

دوره 61 12  شماره 

صفحات  -

تاریخ انتشار 1998